🔬 Introduction
Ceftibid-OF Dry Syrup is a powerful combination antibiotic containing Cefixime (a third-generation cephalosporin) and Ofloxacin (a fluoroquinolone). This dual-action formula provides broad-spectrum coverage against both Gram-positive and Gram-negative bacteria, making it highly effective for treating respiratory, gastrointestinal, and urinary tract infections in children.
⚕️ Pharmacokinetics & Bioavailability
✔ Cefixime Absorption: Well absorbed from the gastrointestinal tract (~40–50%)
✔ Ofloxacin Absorption: Rapidly absorbed (~95%)
✔ Peak Plasma Concentration: 2–4 hours after administration
✔ Protein Binding: Cefixime (~65%), Ofloxacin (~32%)
✔ Half-life: Cefixime (~3–4 hours), Ofloxacin (~5–6 hours)
✔ Excretion: Cefixime – 50% in urine, Ofloxacin – 75–80% in urine
🦠 Indications & Uses
🚑 Ceftibid-OF Dry Syrup is prescribed for:
✔ Respiratory Tract Infections (Tonsillitis, Pharyngitis, Bronchitis, Pneumonia)
✔ Urinary Tract Infections (UTI) (Cystitis, Pyelonephritis)
✔ Gastrointestinal Infections (Typhoid Fever, Bacterial Diarrhea, Dysentery)
✔ Skin & Soft Tissue Infections (Impetigo, Cellulitis)
✔ Ear Infections (Otitis Media)
💊 Dosage & Administration
✔ Children (Based on Body Weight):
Weight | Dose (Once Daily) | Dose (Twice Daily) |
5-9 kg | 2.5 mL | 1.25 mL |
10-19 kg | 5 mL | 2.5 mL |
20-29 kg | 7.5 mL | 3.75 mL |
30-40 kg | 10 mL | 5 mL |
📌 Administration: Shake well before use. Can be taken with or without food.
⚙️ Mechanism of Action
✔ Cefixime: Inhibits bacterial cell wall synthesis, causing bacterial lysis and death (bactericidal action)
✔ Ofloxacin: Inhibits bacterial DNA replication, preventing growth and multiplication (bactericidal action)
✔ Effective Against: Streptococcus, Haemophilus influenzae, Escherichia coli, Salmonella, Klebsiella, Proteus, Pseudomonas aeruginosa
⚠️ Warnings & Precautions
❌ Penicillin Allergy: Cross-sensitivity with cephalosporins may occur
❌ Renal Impairment: Dose adjustment required in severe cases
❌ Tendonitis Risk (Ofloxacin): Avoid in children with joint disorders
❌ Clostridium difficile Infection: Risk of antibiotic-associated diarrhea
❌ Superinfection Risk: Prolonged use may lead to fungal or resistant bacterial infections
🚨 Adverse Effects
✔ Common: Nausea, vomiting, diarrhea, abdominal pain, dizziness
✔ Serious: Allergic reactions, liver enzyme elevation, tendonitis, pseudomembranous colitis
⚡ Drug Interactions
⚡ Antacids (Containing Magnesium/Aluminum): Reduce antibiotic absorption
⚡ Probenecid: Increases Cefixime levels, prolonging its effect
⚡ NSAIDs (Ibuprofen, Diclofenac): May increase seizure risk with Ofloxacin
⚡ Warfarin & Anticoagulants: Increases bleeding risk
⚡ Live Vaccines (e.g., Typhoid Vaccine): May reduce vaccine efficacy
📦 Storage Conditions
📌 Store in a cool, dry place below 25°C
📌 After reconstitution, use within 7 days (keep refrigerated)
📌 Keep out of reach of children
🏆 Conclusion
Ceftibid-OF Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg) is a highly effective combination antibiotic for treating pediatric bacterial infections. Its dual mechanism of action ensures broader coverage and faster recovery.
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🚀 Ceftibid-OF – Dual-Action Formula for Faster Infection Recovery! 💊💪
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📧 Email: info@minovalifesciences.com
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