Ursodeoxycholic acid

Drug Class: Gallstone dissolution agent

• Ursodeoxycholic acid (UDCA) is a steroid bile acid approved for primary biliary cirrhosis, also widely used for the treatment of cholestatic liver diseases 

• UDCA is reported to have “hepato-protective properties” and possesses multiple mechanisms of action.

• Helps in reducing gallstone volume, number, or both, without apparent dose dependence, a safe & effective alternative to surgery in selected patients with gallstones.

• Previously used for cholesterol gallstone dissolution, is currently considered the first choice therapy for many cholestatic syndromes.

• Demonstrates the beneficial effect on liver function in children after successful surgery for biliary atresia.

• Early UDCA therapy is beneficial for slowing down the progression of liver pathology.