Gliclazide

Sulfonylurea (insulin secretagogues)

• Effectively lowers the level of glycated hemoglobin (HbA1c) across a broad range of patients with type 2 diabetes.
• Possesses antioxidant properties, reduces markers of endothelial inflammation, and prevents glucose-induced apoptosis of endothelial cells.

Metformin

Drug class: Biguanides

• Potent antihyperglycaemic agent for type 2 diabetes that efficiently decreases hepatic glucose production.
• Safe for normal to obese type 2 diabetes patients.
• Metformin (MET) is widely considered to be the best first step in oral antidiabetic treatment, not only because of its efficacy in reducing the glycosylated hemoglobin A_1c (HbA_1c), but also due to its low risk for hypoglycemia, its positive or neutral effect on body weight, its rare incidence of adverse effects, and its low cost.