Moxifloxacin

• A novel fourth-generation fluoroquinolone
• Acts by interfering with the bacterial DNA replication process
• Known to be highly effective against both gram-positive and negative organisms

Tobramycin

• A bactericidal drug that acts by primarily inhibiting protein synthesis
• Useful in controlling both superficial and deep infections of the eye and ocular adnexa
• In a study about antibiotic resistance in bacteria causing eye infections, it was found S. aureus’s resistance to tobramycin had decreased little but significantly.

Combination

• Both Tobramycin and Moxifloxacin in eye drops are equally effective as empirical therapy when used in acute bacterial conjunctivitis
• High rates of clinical cure were achieved with both agents with negligible side effects.