⚙️ Pharmacokinetics & Bioavailability

Vildagliptin:

• Rapid oral absorption, bioavailability ~85%

• Onset within 1–2 hours

• Metabolized by hydrolysis, excreted via urine

Metformin:

• Absorbed in small intestine

• Not metabolized, excreted unchanged in urine

• Onset of action within hours

📌 Indications & Uses

The Vildafast range is indicated for:

• Type 2 Diabetes Mellitus (T2DM)

• Patients not controlled by Metformin alone

• Combination therapy with insulin or sulfonylureas

• First-line or second-line oral antidiabetic regimen

🕒 Dosage & Administration

✅ Vildafast-M-1000 / 500 Tablets

• 1 tablet once or twice daily with meals

• Start with 500mg Metformin and increase gradually

✅ Vildafast-50 Tablet

• Usually 50mg twice daily as monotherapy or with insulin

Dosage to be adjusted by physician based on glucose levels & patient tolerance.

❌ Contraindications

• Type 1 Diabetes Mellitus

• Diabetic ketoacidosis

• Renal or hepatic impairment

• History of lactic acidosis

• Hypersensitivity to any component

⚠️ Warnings & Precautions

• Monitor renal function regularly

• Avoid alcohol (increased risk of lactic acidosis)

• Use cautiously in aged patients

• Not recommended during pregnancy or lactation

❗ Adverse Effects

Common:

• Nausea, vomiting, abdominal pain

• Diarrhea

• Headache

Serious (Rare):

• Lactic acidosis (Metformin)

• Pancreatitis (Vildagliptin – very rare)

• Hypoglycemia (with insulin/sulfonylureas)

💊 Drug Interactions

• ACE inhibitors – may enhance glucose-lowering effects

• Diuretics, corticosteroids – may reduce effectiveness

• Alcohol – avoid due to lactic acidosis risk

• Iodinated contrast agents – temporarily stop Metformin

🪒 Storage Conditions

• Store below 30°C, away from sunlight and moisture

• Keep tablets in the original pack

• Do not refrigerate

🔹 Conclusion

The Vildafast range from Minova Life Sciences combines the efficacy of Vildagliptin and Metformin to manage blood sugar levels effectively and safely. Whether used as monotherapy or in combination, these tablets offer optimal glycemic control and improved patient outcomes.

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